The Science of Dioxin

July 31, 2015 | Appeals | Complex Torts & Product Liability

Paper Finds Loss of Tiparp Increased Sensitivity to Dioxin Toxicity and Lethality

A paper published in The Journal of Biological Chemistry has concluded that the loss of the mono-ADP-ribosyltransferase, Tiparp, increased sensitivity to dioxin-induced steatohepatitis and lethality.

Tiparp is an aryl hydrocarbon receptor (“AHR”) repressor, but its role in dioxin toxicity has been unknown. Now, The Journal of Biological Chemistry has published a paper titled “Loss of the Mono-ADP-ribosyltransferase, Tiparp, Increases Sensitivity to Dioxin-induced Steatohepatitis and Lethality,” by Shaimaa Ahmed, Debbie Bott, Alvin Gomez, Laura Tamblyn, Adil Rasheed, Tiffany Cho, Laura MacPherson, Kim S. Sugamori, Yang Yang, Denis M. Grant, Carolyn L. Cummins, and Jason Matthews.

The authors concluded in their paper that the loss of Tiparp, an ADP-ribosyltransferase and AHR repressor, increased sensitivity to dioxin-induced toxicity, steatohepatitis, and lethality in mice.

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